Mastering the cognitive knowledge within a field such as pediatrics is a formidable task. It is even more difficult to draw on that knowledge, procure and filter through the clinical and laboratory data, develop a differential diagnosis, and finally form a rational treatment plan. To gain these skills, the student often learns best at the bedside, guided and instructed by experienced teachers, and inspired toward self-directed, diligent reading. Clearly, there is no replacement for education at the bedside. Unfortunately, clinical situations usually do not encompass the breadth of the specialty. Perhaps the best alternative is a carefully crafted patient case designed to stimulate the clinical approach and decision making. In an attempt to achieve that goal, we have constructed a collection of clinical vignettes to teach diagnostic or therapeutic approaches relevant to pediatrics. Most importantly, the explanations for the cases emphasize the mechanisms and underlying principles, rather than merely rote questions and answers. This book is organized for versatility. It allows the student “in a rush” to go quickly through the scenarios and check the corresponding answers, while allowing the student who wants more thought-provoking explanations to go at a more measured pace. The answers are arranged from simple to complex: a summary of the pertinent points, the bare answers, an analysis of the case, an approach to the topic, comprehension questions at the end for reinforcement and emphasis, and a list of references for further reading. A listing of cases is included in Section III to aid the student who desires to test his or her knowledge of a specific area or who wants to review a topic. Finally, we intentionally did not primarily use a multiple-choice question format in our clinical case scenarios because clues (or distractions) are not available in the real world. Nevertheless, several multiple-choice comprehension questions are included at the end of each case discussion to reinforce concepts or introduce related topics.