We appreciate all the kind remarks and suggestions from the many medical students over the past 3 years. Your positive reception has been an incredible encouragement since the inception of the Case Files^® series. In this sixth edition of Case Files^®: Pediatrics, the basic format of the book has been retained. Improvements were made in updating many of the sections, including grouping of the cases in a more logical order for students to more easily cross-reference cases. We have also used case correlations to assist further. We reviewed the clinical scenarios and revised several of them, keeping their “real-life” presentations patterned after actual clinical experience. We have written seven new cases, including Infant Rashes, Accidental Drug Ingestion, Anemia in the Pediatric Patient, Pelvic Inflammatory Disease, Patent Ductus Arteriosus, Myasthenia Gravis, and Juvenile Idiopathic Arthritis. We have used a bulleted format for the summary for easier reading and correlated entrustable professional activities (EPAs) for the learning objectives. The multiple-choice questions have been carefully reviewed and rewritten to ensure that they comply with the National Board and USMLE format, and the Review Questions (Section III) have been updated for the student to test their knowledge after reading the book. Through this sixth edition, we hope that the reader will continue to enjoy learning how to diagnose and manage patients through the simulated clinical cases. It certainly is a privilege to be teachers for so many students, and it is with humility that we present this edition.